The service experience of civil aircraft engines shows that the uncontained engine rotors failure still occurs. In order to minimize the hazards possibly caused by this uncontained rotor failure, based on a civil aircraft with an engine mounted on the wings, combining the requirements of the advisory circular AC20-128A and the engineering experience of civil aircraft design, the research on aircraft internal system layout and structural protection design was carried out. Firstly, this paper introduces the design process and analysis model to minimize the hazards of the uncontained engine rotors failure, and focuses on the design ideas and methods in five aspects from the perspective of CAAC review, including uncontrolled fire, loss of thrust, loss of airplane control, passengers and crew incapacitation, and structural integrity. The research results show that during the design of the aircraft, the hazards of the uncontained engine rotors failure to the aircraft can be minimized by taking preventive measures, such as locating the critical components or systems outside the likely debris impact areas, duplicate and separate design, and providing suitable protection if located in debris impact areas, which have guiding significance for the design and airworthiness verification of the uncontained engine rotors failure.