High-performance composite materials were widely applied in civil aircraft structure. The fabrication of composite aircraft structures was usually achieved by cooperation of manufacturer and suppliers. The article describes airworthiness tye certification requirements for fabrication of composite aircraft structures, and introduces the airworthiness requirements for equivalency substantiation of composite structure manufacturing process changes. At present, equivalency substantiation should be based on a comparability study among the physical, chemical and mechanical performances of the material fabricated by accepted process and follow-on process. At last, the successful criterion for equivalency substantiation of composite structure manufacturing process changes is presented.The methods in this paper provide guidelines to type certification applicants and help them to show compliance with airworthiness requirements when the composite structures were fabricated by different suppliers. The methods could be used as reference for quality control of composite fabrication in other industry field.