The paper researched on the transmission loss of the fuselage typical panel based on the statistical energy analysis (SEA) method.According to the theory of SEA, the paper got the formula about the transmission loss of the acoustic system consist of the sound source, the transfer and the receiving cavity. Through making clear the model, we set up the prediction SEA model of the fuselage panel and acquired the transmission loss curve.It was proved that the numerical model is efficient after comparing with the test data. So that we applied the method into development and design the transmission loss performance about the real fuselage panel including the skin, insulation blanket and interior panel.