Tests are essential to ensure airplane safety in various extreme weather, and to verify system function and performance in the airplane environmental envelope. Natural extreme weather is difficult to capture and long time to wait for, also it has short duration. Artificial weather conditions like extreme hot, extreme cold, freezing fog, freezing drizzle, blowing snow could be achieved in climatic laboratory, without constraint of natural environment. Test efficiency could be effectively improved and test cycle could be shortened. It’s an effective mean for modern airliner manufacture for extreme weather tests. Significance of climatic laboratory, status of global climate laboratories are introduced. The report focuses on the test condition simulated and tests had been conducted in Mckinley Climatic laboratory. Test objectives, test contents, test methods, test hazards and mitigations are elaborated 〖JP3〗based on practical experience. The test results can provide a reference for subsequent airplane climatic laboratory test.