Under the COVID-19 epidemic, in order to reduce the mutual infection among cabin passengers, the propagation characteristics of COVID-19 virus and the airflow organization in the cabin of wide-body commercial aircraft were studied in this paper, and a personalized mini-environment control technology was proposed to suppress the transmission of the virus in the cabin. The Lagrangian method was used to simulate the virus droplets exhaled by a passenger in the cabin, revealing the transmission trajectory and distribution characteristics of virus particles in the cabin. The effects of different air supply modes, air supply velocity and personalized mini-environment control technology on the propagation characteristics of virus particles in the cabin were studied. The impact of virus droplets on passengers in different positions was quantitatively analyzed by relative exposure value. The results show that the influence of different air supply velocity on virus droplet transportation in cabin can be ignore, but the combination of top and side air supply can effectively reduce the spread range of virus droplet. By adjusting the personalized mini-environment and adding air curtain supply method, the concentration of virus droplets in the cabin can be effectively reduced, and the risk of cross-infection can be reduced. The relative exposure value of passengers in adjacent positions can be reduced by 65%, and that of passengers in other positions by about 90%.