Mean time to failure (MTTF) and mean failure rate of rolling bearings are significant basic data for revolving mechanical equipment reliability prediction and analysis. The confidence degree of conventional MTTF and data of rolling bearing rooted in statistical sample information is not high, so it is difficult to restrict reliability quantitative design of rolling bearing. Utilizing calculation method for fatigue life of rolling bearing, based on the relationship study of rolling bearing life and its reliability, deduced calculation formula for MTTF and mean failure rate of Weibull distribution, this paper provides a kind of calculation method and procedure for MTTF and of rolling bearing, also provides a calculation example. The problem of utilizing design parameters (life/reliability/dynamic load, etc.) to calculate the MTTF and mean failure rate of rolling bearing is solved, which can provide data and method support for rolling bearing and assembled product reliability prediction and analysis.