In this paper, the composite material fuselage wall plate and its composed configuration with thermal acoustic insulation blanket were studied. Based on CCAR25R4 airworthiness standard and heat release rate (HRR) test method, the HRR characteristics of the composite fuselage panel and the composite fuselage panel were tested and analyzed, and the effects of different factors on the HRR characteristics were analyzed. The results show that the HRR of the composite fuselage panel meets the requirement of peak heat release rate specified in current airworthiness standard, but the total heat release does not meet the airworthiness requirements. The results show that the HRR of composite material fuselage wall plate and derivative configurations meet the requirements of peak heat release rate specified in airworthiness standard.