Based on the vibration of aircraft structure and the noise inside cabin, an active noise control system using FXLMS (Filteredx Least Mean Square) algorithm is designed to reduce the cabin noise caused by engine rotors. Firstly, the basic principle of active noise control technology and the algorithm used in this paper are described briefly. Then the cabin noise and structural vibration signals collected by the microphones and the vibration sensors are analyzed. Based on the analysis results, the distribution of the sound field in the cabin space is calculated, and the microphones are arranged in the noisy areas as the target zone for the active noise control system. The coherences between structural vibration signals and cabin noise signals are calculated according to the coherence principle, and the vibrational sensor with the highest coherence is selected as the reference input for the active noise control system. Finally, several loudspeakers are installed in the cabin as secondary sound sources to test the secondary path transfer functions between them and the microphones in the target area. According to the secondary path transfer functions and combining the vibration and noise data, simulations are carried out. The simulation results show that the active noise control system designed in the paper can achieve obvious noise reduction effect in the target area.