The design of high-lift devices is very important for large commercial aircraft. Variable camber high-lift devises are the development trend of large passenger aircraft in the future, and is also the current research hot spot. The inner airfoil of a large wide body aircraft is taken as the research object. Driven by the flexible bending mechanism inside the flaps, the last 50% of the flaps can be flexibly bent. Based on the original rigid flap, the optimal configuration can increase the camber of the trailing edge of the flap by 8°. Then, driven by the three-dimensional trailing edge hinge flap mechanism, and using the flexible bending mechanism inside the flap, the “droop nose + trailing edge flap of variable camber + simple hinged trailing edge flap combined with spoiler downward de-flection” is adopted to optimize the two-dimensional aerodynamic / mechanical integration of take-off and landing configuration. Compared with the original airfoil with inflexible bending, the optimized results showed that the increase of the maximum lift coefficient of the takeoff configuration and the increase of the maximum lift coefficient of the landing configuration was 0.119 and 0.162 respectively, and the optimal landing configuration delayed stall at an angle of attack by 1°.