In the development of civil aircraft, main manufacturersupplier mode is usually chosen. With the increasing complex and integrated aircraft and system, it is necessary to follow certain development process guidelines to ensure compliance with related airworthiness regulations. How to monitor the design process to ensure that aircraft/system is designed in according with the plans and standards, and to preserve the evidence, is an important focus in airworthiness certification. In part, it can provide confidence that the main manufacturer’s process assurance system is perfect and the supplier can be controlled comprehensively. Based on ARP4754A, this article has researched on process assurance management method applied by manufacturer for civil aircraft adapting the manufacturersupplier mode. It focused on process assurance concept, manufacturer process assurance phase review method, and supplier process assurance monitoring method, to describe the process assurance management method for aircraft design, which can provide certain reference for the design process to meet the design requirements confidence.