The establishing Design Assurance System by OEM is aimed to promote the ability of air worthinessautonomously, the functions of design, airworthiness and independent supervision are implemented through organization, responsibility, procedures and resources to ensure that the design or design changes of aviation products meets the requirements of airworthiness authority. Among them, the airworthiness independent verification is the critical point of the airworthiness function for Design Assurance System. Based on the specific analysis of the airworthiness independent verification function of Design Assurance System, this paper puts forward the mechanism of realizing independent verification from the planning and design level of Design Assurance System, and gives suggestions on the responsibility subject, responsibility, qualification requirements, workflow, supporting tools, and management procedures, etc., and from the technical support of big data knowledge, and in the two aspects of stepbystep talent training guarantee, the function and effect of airworthiness independent verification are deepened by continuously optimizing and improving methods, tools and manpower allocation, so as to enhance the guarantee function of design assurance system for aircraft model development.