Aiming at the problem of inadequate consideration of aeroelasticity and inadequate consideration of aerodynamic/structural coupling in the optimization of the flying wing aircraft, this article use a kind of parametric modeling method for the CFD (Computational Fluid Dynamics) aerodynamic model, flat aerodynamic model and threedimensional panelbar model of the wing, and set up a set of prospective design methods based on Kriging model. By optimum design, the optimal aerodynamic shape and structural configuration of the wing are obtained, which has smaller aerodynamic drag and weight than the initial threedimensional panelbar model of the wing. On the premise of satisfying precision and calculating efficiency, the subsonic doublet grid method and the CFD method based on Euler equation are selected for the aerodynamic subdiscipline, while the finite element analysis method is adopted for the structural subdiscipline and the genetic algorithm is used for optimization algorithm.