It is an indisputable fact that human error is the main cause induced by major civil aircraft accidents. There have been much studies and recommendations for the causes and prevention induced by human error. Combined with the airworthiness regulations of the FAA and EASA FAR/CS 25.1302,this paper analyzed and discussed the challenges and approaches to reducing design-induced pilot human error,focused on the flight deck design and certification perspectives. Finally, a series of recommendations is provided to develop the work.