Based on the three essentials of fire and the principle of fire generating, the physical zones of civil aircraft are divided into four types of fire prevention zones. Based on the research and analysis of fire prevention design measures and their applicability, according to the characteristics and status of the three essentials of fire, the requirements for fire prevention design and the measures which should be considered and adapted are established for each type of zones. The reference and guidance for fire safety design and analysis of civil aircraft are provided.