The fatigue and corrosion problems of some metallic parts will often occur due to alternating load and severe environment condition during aircraft’s service period. The surface treatment process was always utilized to improve fatigue and wear crack propagation resistance performance by inducing compressive stress through thickness direction. Laser shock peening (LSP) is an effective laser-based surface processing technique to enhance surface strength and extend fatigue life of metallic part. In this paper, the trajectory planning and generation platform was developed and integrated into CATIA software. The platform could achieve the functions by integrating trajectory planning, generation, visualization and results output with extraction of CAD geometric features in peening zone. And then the platform was used to generate peening path of machined frame for aircraft cargo door bulkhead. The deformation behavior of machined frame was studied in terms of stress, strain and deformed displacement after LSP by ABAQUS subroutine analysis. The results show that maximum compressive stress locates 1.0 mm below the surface and with equivalent strain of 0.03~0.04 at the same location by giving LSP process parameters in this paper. The average deformed displacement is about 50 μm in typical peening region. Besides, the finite element analysis of LSP for machined frame also validates the suitability of trajectory planning and generation in the aforementioned integration platform.