Titanium alloy is widely used in aviation industry, such as the pylon track of typical structures for civil aircraft. Titanium alloy as a difficult materials, is usually processed by drilling. Different drilling parameters correspond to different drilling temperature and drilling force, while drilling temperature and drilling force have great influence on machining precision. In order to match the drilling parameters with machining precision well, the software named Deform 3D was used to establish a finite element model of titanium alloy thermal stress coupling, and simulate the drilling force and drilling temperature during the machining process. Firstly, the drilling bits and titanium alloy samples were meshed. Secondly, the constitutive model and breakaway criterion of titanium alloy material were established, and the drilling force and temperature were obtained by simulation software. Finally, the drilling temperature and drilling force were obtained by test, and compared with the simulation results. The results show that the simulation results are in good agreement with the experiment, the error is within 15%, and the simulation can provide effective drilling force and drilling temperature.