The traditional method for engineers to obtain material allowable values is to test various forms of materials and specimens and to verify elements, subcomponents, and components step by step according to the “building block” approach. However, the cost of testing in accordance with the “building block” method is high. Therefore, a new method is needed to develop, identify advanced material technologies in such a short time and promote its application in engineering. According to FAA/ASTM recommendations, multiscale modeling/virtual testing can be a validation strategy early in the design application process. Based on material meso-mechanics/macro mechanics, manufacturing processes, test data and service environment impact and combined with progressive failure analysis to predict structure/component safety, Application process of multi-scale virtual testing has been set up. This paper applies the mature commercial software GENOA developed by AlphaSTAR in the United States, which uses unidirectional tape test statistics to reverse the performance of fiber and matrix materials and the uncertainty of manufacturing variables. Later on, the uncertainties are used to generate random virtual test specimens of the laminate structure and calculate the allowable values. This simulation method has been successfully applied in the T800H project, which greatly reduced the physical test.